Progesterone concentrations on blastocyst transfer day in modified natural cycle frozen embryo transfer cycles
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Progesterone concentrations on blastocyst transfer day in modified natural cycle frozen embryo transfer cycles. / Saupstad, Marte; Bergenheim, Sara J.; Bogstad, Jeanette W.; Petersen, Morten R.; Klajnbard, Anna; Prætorius, Lisbeth; Freiesleben, Nina l.C.; Englund, Anne L.; Løkkegaard, Ellen C.L.; Knudsen, Ulla B.; Husth, Merete; Alsbjerg, Birgit; Møller, Julie E.; Dam, Tine V.; Forman, Julie L.; Pinborg, Anja; Løssl, Kristine.
I: Reproductive BioMedicine Online, Bind 49, Nr. 1, 103862, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Progesterone concentrations on blastocyst transfer day in modified natural cycle frozen embryo transfer cycles
AU - Saupstad, Marte
AU - Bergenheim, Sara J.
AU - Bogstad, Jeanette W.
AU - Petersen, Morten R.
AU - Klajnbard, Anna
AU - Prætorius, Lisbeth
AU - Freiesleben, Nina l.C.
AU - Englund, Anne L.
AU - Løkkegaard, Ellen C.L.
AU - Knudsen, Ulla B.
AU - Husth, Merete
AU - Alsbjerg, Birgit
AU - Møller, Julie E.
AU - Dam, Tine V.
AU - Forman, Julie L.
AU - Pinborg, Anja
AU - Løssl, Kristine
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Research question: Are serum progesterone concentrations on the day of modified natural cycle (mNC) frozen blastocyst transfer (FET) without luteal phase support (LPS) associated with clinical pregnancy rate (CPR)? Design: Data were collected between January 2019 and October 2022 as a sub-study of an ongoing randomized controlled trial assessing pregnancy outcomes in mNC-FET. The sub-study included all women (n = 209) randomized to mNC-FET without LPS at the time of data extraction. Participants were aged 18–41 years, had regular menstrual cycles and underwent mNC-FET treatment with single-blastocyst transfer. Associations between the serum progesterone concentration on the day of blastocyst transfer and CPR, pregnancy rate and pregnancy loss rate (PLR) were examined between groups with low and higher progesterone concentrations using the 25th and 10th percentiles as cut-offs. Multivariate logistic regression analyses were performed to adjust for potential confounding factors. Results: Progesterone concentrations on the day of blastocyst transfer in mNC-FET without LPS ranged from 4.9 to 91.8 nmol/l, with the 25th and 10th percentiles at 29.0 nmol/l and 22.5 nmol/l, respectively. Serum progesterone concentrations did not differ between women with or without a clinical pregnancy (mean [SD] 38.5 [14.0] versus 36.8 [12.4] nmol/l; P = 0.350). Furthermore, the CPR, pregancy rate and PLR were similar in women with low or high progesterone concentrations when using the 25th or the 10th progesterone percentile as cut-off. Multivariate regression analyses showed no association between progesterone concentrations and CPR. Conclusions: No association was found between progesterone concentration on the day of blastocyst transfer and pregnancy outcome in women undergoing mNC-FET without progesterone LPS.
AB - Research question: Are serum progesterone concentrations on the day of modified natural cycle (mNC) frozen blastocyst transfer (FET) without luteal phase support (LPS) associated with clinical pregnancy rate (CPR)? Design: Data were collected between January 2019 and October 2022 as a sub-study of an ongoing randomized controlled trial assessing pregnancy outcomes in mNC-FET. The sub-study included all women (n = 209) randomized to mNC-FET without LPS at the time of data extraction. Participants were aged 18–41 years, had regular menstrual cycles and underwent mNC-FET treatment with single-blastocyst transfer. Associations between the serum progesterone concentration on the day of blastocyst transfer and CPR, pregnancy rate and pregnancy loss rate (PLR) were examined between groups with low and higher progesterone concentrations using the 25th and 10th percentiles as cut-offs. Multivariate logistic regression analyses were performed to adjust for potential confounding factors. Results: Progesterone concentrations on the day of blastocyst transfer in mNC-FET without LPS ranged from 4.9 to 91.8 nmol/l, with the 25th and 10th percentiles at 29.0 nmol/l and 22.5 nmol/l, respectively. Serum progesterone concentrations did not differ between women with or without a clinical pregnancy (mean [SD] 38.5 [14.0] versus 36.8 [12.4] nmol/l; P = 0.350). Furthermore, the CPR, pregancy rate and PLR were similar in women with low or high progesterone concentrations when using the 25th or the 10th progesterone percentile as cut-off. Multivariate regression analyses showed no association between progesterone concentrations and CPR. Conclusions: No association was found between progesterone concentration on the day of blastocyst transfer and pregnancy outcome in women undergoing mNC-FET without progesterone LPS.
KW - Blastocyst transfer
KW - Clinical pregnancy rate
KW - Frozen embryo transfer
KW - Modified natural cycle
KW - Progesterone
U2 - 10.1016/j.rbmo.2024.103862
DO - 10.1016/j.rbmo.2024.103862
M3 - Journal article
C2 - 38735231
AN - SCOPUS:85192720913
VL - 49
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 1
M1 - 103862
ER -
ID: 392449093