Combined hormonal contraception and risk of venous thromboembolism within the first year following pregnancy. Danish nationwide historical cohort 1995-2009
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Combined hormonal contraception and risk of venous thromboembolism within the first year following pregnancy. Danish nationwide historical cohort 1995-2009. / Petersen, Jesper Friis; Bergholt, T; Nielsen, A. K.; Paidas, M J; Løkkegaard, E C L.
I: Thrombosis and Haemostasis, Bind 112, Nr. 1, 03.07.2014, s. 73-78.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Combined hormonal contraception and risk of venous thromboembolism within the first year following pregnancy.
T2 - Danish nationwide historical cohort 1995-2009
AU - Petersen, Jesper Friis
AU - Bergholt, T
AU - Nielsen, A. K.
AU - Paidas, M J
AU - Løkkegaard, E C L
PY - 2014/7/3
Y1 - 2014/7/3
N2 - Estimating the risk of venous thromboembolism (VTE) associated with combined hormonal contraceptives following early terminated pregnancies or birth, a Danish nationwide retrospective cohort observing a one-year follow-up was defined using three unique registries. All Danish women with confirmed pregnancies aged 15-49 during the period of 1995-2009 were included. The main outcomes were relative and absolute risks of first time venous thromboembolism in users as well as non-users of combined hormonal contraceptives. In 985,569 person-years, 598 venous thromboembolisms were recorded. After early terminated pregnancies and births, respectively, 113 and 485 events occurred in 212,552 and 773,017 person-years. After early terminated pregnancies, the crude VTE incidence ratios were similar, and the numbers needed to harm were equal between groups that did or did not use combined hormonal contraceptives throughout the follow-up year. After childbirth, individuals that used combined hormonal contraceptives were more likely than non-users to experience VTE depicted by crude incidence ratios; however, the difference was only significant after 14 weeks. This implied that the numbers needed to harm were lower for those that used compared to those that did not use combined oral contraceptives in the initial 14 weeks postpartum. In conclusion, the use of combined hormonal contraceptives after early terminated pregnancies was not detrimental, but during the puerperal period, they should be used with caution.
AB - Estimating the risk of venous thromboembolism (VTE) associated with combined hormonal contraceptives following early terminated pregnancies or birth, a Danish nationwide retrospective cohort observing a one-year follow-up was defined using three unique registries. All Danish women with confirmed pregnancies aged 15-49 during the period of 1995-2009 were included. The main outcomes were relative and absolute risks of first time venous thromboembolism in users as well as non-users of combined hormonal contraceptives. In 985,569 person-years, 598 venous thromboembolisms were recorded. After early terminated pregnancies and births, respectively, 113 and 485 events occurred in 212,552 and 773,017 person-years. After early terminated pregnancies, the crude VTE incidence ratios were similar, and the numbers needed to harm were equal between groups that did or did not use combined hormonal contraceptives throughout the follow-up year. After childbirth, individuals that used combined hormonal contraceptives were more likely than non-users to experience VTE depicted by crude incidence ratios; however, the difference was only significant after 14 weeks. This implied that the numbers needed to harm were lower for those that used compared to those that did not use combined oral contraceptives in the initial 14 weeks postpartum. In conclusion, the use of combined hormonal contraceptives after early terminated pregnancies was not detrimental, but during the puerperal period, they should be used with caution.
KW - Abortion, Induced
KW - Adolescent
KW - Adult
KW - Cohort Studies
KW - Contraceptives, Oral, Hormonal
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Incidence
KW - Middle Aged
KW - Postpartum Period
KW - Registries
KW - Retrospective Studies
KW - Risk
KW - Treatment Outcome
KW - Venous Thromboembolism
KW - Young Adult
U2 - 10.1160/TH13-09-0797
DO - 10.1160/TH13-09-0797
M3 - Journal article
C2 - 24499991
VL - 112
SP - 73
EP - 78
JO - Thrombosis et diathesis haemorrhagica
JF - Thrombosis et diathesis haemorrhagica
SN - 0340-6245
IS - 1
ER -
ID: 137672947