Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring: A Danish Nationwide Cohort Study
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Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring : A Danish Nationwide Cohort Study. / Rom, Ane Lilleøre; Wu, Chun Sen; Olsen, Jørn; Jawaheer, Damini; Hetland, Merete Lund; Mørch, Lina Steinrud.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 57, No. 1, 01.01.2018, p. 28-32.e1.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring
T2 - A Danish Nationwide Cohort Study
AU - Rom, Ane Lilleøre
AU - Wu, Chun Sen
AU - Olsen, Jørn
AU - Jawaheer, Damini
AU - Hetland, Merete Lund
AU - Mørch, Lina Steinrud
N1 - Copyright © 2017 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - OBJECTIVE: Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming.METHOD: The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children.RESULTS: Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06-1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97-1.82).CONCLUSION: Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.
AB - OBJECTIVE: Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming.METHOD: The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children.RESULTS: Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06-1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97-1.82).CONCLUSION: Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.
KW - autism spectrum disorders
KW - maternal history
KW - offspring
KW - parental history
KW - rheumatoid arthritis
U2 - 10.1016/j.jaac.2017.10.002
DO - 10.1016/j.jaac.2017.10.002
M3 - Journal article
C2 - 29301665
VL - 57
SP - 28-32.e1
JO - American Academy of Child and Adolescent Psychiatry. Journal
JF - American Academy of Child and Adolescent Psychiatry. Journal
SN - 0890-8567
IS - 1
ER -
ID: 209572523