Increased Suicide Risk in Patients with Hidradenitis Suppurativa
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Increased Suicide Risk in Patients with Hidradenitis Suppurativa. / Thorlacius, Linnea; Cohen, Arnon D; Gislason, Gunnar H; Jemec, Gregor B E; Egeberg, Alexander.
In: The Journal of Investigative Dermatology, Vol. 138, No. 1, 2018, p. 52-57.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased Suicide Risk in Patients with Hidradenitis Suppurativa
AU - Thorlacius, Linnea
AU - Cohen, Arnon D
AU - Gislason, Gunnar H
AU - Jemec, Gregor B E
AU - Egeberg, Alexander
N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Patients with skin disorders are considered at a higher risk of depression and anxiety than the background population. Patients with hidradenitis suppurativa (HS) may be particularly affected. We explored the association between HS and depression, anxiety, and completed suicides in the Danish national registries, expanding to include data on suicidal behavior, using both a cross-sectional and a cohort study design. Both designs included 7,732 patients with HS and a background population of 4,354,137. The cohort study revealed that HS patients had an increased risk of completed suicide after adjustment for confounding factors (11 per 7,732 vs. 2,904 per 4,354,137) (hazard ratio [95% confidence interval] = 2.42 [1.07-5.45]; P = 0.0334) and an increased risk of antidepressant drug use (1.30 [1.17-1.45]; P < 0.0001). In contrast to previous studies, the cross-sectional baseline data revealed nonsignificant association with depression (odds ratio [95% confidence interval] = 1.13; 0.87-1.47]; P = 0.36 and hospitalization due to depression (1.32 [0.94-1.85]; P = 0.1083). To the best of our knowledge, no previous studies have reported on the increased risk of completed suicide among HS patients. The increased risk of completed suicide is not solely explained by lifestyle and demographic differences and the results highlight the profound impact HS has on the lives of patients with this often devastating disease.
AB - Patients with skin disorders are considered at a higher risk of depression and anxiety than the background population. Patients with hidradenitis suppurativa (HS) may be particularly affected. We explored the association between HS and depression, anxiety, and completed suicides in the Danish national registries, expanding to include data on suicidal behavior, using both a cross-sectional and a cohort study design. Both designs included 7,732 patients with HS and a background population of 4,354,137. The cohort study revealed that HS patients had an increased risk of completed suicide after adjustment for confounding factors (11 per 7,732 vs. 2,904 per 4,354,137) (hazard ratio [95% confidence interval] = 2.42 [1.07-5.45]; P = 0.0334) and an increased risk of antidepressant drug use (1.30 [1.17-1.45]; P < 0.0001). In contrast to previous studies, the cross-sectional baseline data revealed nonsignificant association with depression (odds ratio [95% confidence interval] = 1.13; 0.87-1.47]; P = 0.36 and hospitalization due to depression (1.32 [0.94-1.85]; P = 0.1083). To the best of our knowledge, no previous studies have reported on the increased risk of completed suicide among HS patients. The increased risk of completed suicide is not solely explained by lifestyle and demographic differences and the results highlight the profound impact HS has on the lives of patients with this often devastating disease.
KW - Adult
KW - Anxiety/epidemiology
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Denmark/epidemiology
KW - Depression/epidemiology
KW - Female
KW - Hidradenitis Suppurativa/complications
KW - Humans
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Proportional Hazards Models
KW - Registries/statistics & numerical data
KW - Risk Factors
KW - Suicide/psychology
U2 - 10.1016/j.jid.2017.09.008
DO - 10.1016/j.jid.2017.09.008
M3 - Journal article
C2 - 28942360
VL - 138
SP - 52
EP - 57
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 1
ER -
ID: 215785356